(R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol

Base Information

Chemical Name:(R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol
CAS No.:1376622-74-0
Molecular Formula:C₂₇H₃₃NO₃
Molecular Weight:419.564
Hs Code.:

Synonyms:(R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol

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Chemical Property of (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol

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Technology Process of (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol

There total 4 articles about (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1376622-71-7
tert-butyl (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butanoate

: 1376622-74-0
(R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol

Guidance literature:: tert-butyl (R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butanoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With ethyl acetate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.045

Reference yield:

: (R)-N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amine

: 1376622-74-0
(R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

1.3: 12 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; mineral oil;
DOI:10.1016/j.tet.2012.03.045

Reference yield:

: 100-39-0
benzyl bromide

: 1376622-74-0
(R,R,R)-2-benzyloxy-3-[N-(4'-methoxybenzyl)-N-(α-methylbenzyl)amino]butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.tet.2012.03.045