C₁₉H₁₄F₃N₅O

Base Information

Chemical Name:C₁₉H₁₄F₃N₅O
CAS No.:1616385-74-0
Molecular Formula:C₁₉H₁₄F₃N₅O
Molecular Weight:385.348
Hs Code.:

C<sub>19</sub>H<sub>14</sub>F<sub>3</sub>N<sub>5</sub>O

Synonyms:C₁₉H₁₄F₃N₅O

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Chemical Property of C₁₉H₁₄F₃N₅O

Chemical Property:

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Technology Process of C₁₉H₁₄F₃N₅O

There total 9 articles about C₁₉H₁₄F₃N₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 896116-37-3
2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-amine

: 1616388-35-2
5-methyl-4-(trifluoromethyl)-1H-pyrazole-3-carboxylic acid

: 1616385-74-0
C₁₉H₁₄F₃N₅O

Guidance literature:: 5-methyl-4-(trifluoromethyl)-1H-pyrazole-3-carboxylic acid; With benzotriazol-1-ol; at 20 ℃;

2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-amine; at 20 ℃;

Reference yield:

: 402-61-9
5-methyl-1H-pyrazole-3-carboxylic acid

: 1616385-74-0
C₁₉H₁₄F₃N₅O

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butylhydroperoxide / water; dichloromethane / 20 - 50 °C

2.1: benzotriazol-1-ol / 20 °C

2.2: 20 °C

With tert.-butylhydroperoxide; benzotriazol-1-ol; In dichloromethane; water;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1616385-74-0
C₁₉H₁₄F₃N₅O

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 °C

1.2: 20 °C

2.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 1,4-dioxane / Inert atmosphere; Reflux

3.1: tert.-butyl lithium / tetrahydrofuran / -78 - -20 °C

3.2: 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / Inert atmosphere; Reflux

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: benzotriazol-1-ol / 20 °C

7.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; tert.-butyl lithium; palladium diacetate; sodium hydride; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; mineral oil;