4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine

Base Information

Chemical Name:4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine
CAS No.:1572383-42-6
Molecular Formula:C₂₅H₂₄BrN₃O
Molecular Weight:462.389
Hs Code.:

Synonyms:4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine

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Technology Process of 4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine

There total 8 articles about 4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1572383-82-4
C₂₀H₂₀F₃N₃O₄S

: 244205-40-1
(2-bromophenyl)boronic acid

: 1572383-42-6
4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; toluene; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol500328t

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 1572383-42-6
4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid / 2,2,2-trifluoroethanol / 1 h / 55 °C / Inert atmosphere

2: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol; toluene / 3 h / 80 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluorormethanesulfonic acid; potassium carbonate; In methanol; dichloromethane; 2,2,2-trifluoroethanol; toluene; 3: |Suzuki Coupling;
DOI:10.1021/ol500328t

Reference yield:

: 95-55-6
2-amino-phenol

: 1572383-42-6
4-(benzo[d]oxazol-2-yl)-N-(2'-bromobiphenyl-2-yl)-1-methylpiperidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid / 2,2,2-trifluoroethanol / 1 h / 55 °C / Inert atmosphere

2: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol; toluene / 3 h / 80 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluorormethanesulfonic acid; potassium carbonate; In methanol; dichloromethane; 2,2,2-trifluoroethanol; toluene; 3: |Suzuki Coupling;
DOI:10.1021/ol500328t