N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine

Base Information

Chemical Name:N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine
CAS No.:1346242-94-1
Molecular Formula:C₂₅H₂₇F₃N₆O₂
Molecular Weight:500.524
Hs Code.:

Synonyms:N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine

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Chemical Property of N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine

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Technology Process of N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine

There total 21 articles about N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1346245-18-8
C₃₀H₃₅F₃N₆O₄

: 1346242-94-1
N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 - 50 ℃; for 19h; Product distribution / selectivity;

Reference yield: 67.0%

: 753-90-2
trifluoroethylamine

: 1346245-15-5
C₂₄H₂₇N₅O₅S

: 1346242-94-1
N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine

Guidance literature:: at 90 ℃; for 12h; Product distribution / selectivity; sealed tube;

Reference yield:

: 82031-32-1
7-bromo-1H-quinoxalin-2-one

: 1346242-94-1
N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N'-(2,2,2-trifluoroethyl)propane-1,3-diamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / 2 h / 100 °C

1.2: Cooling with ice

2.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 4 h / Reflux

3.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 90 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C / Inert atmosphere

4.2: 5 - 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5.2: Cooling with ice

6.1: triethylamine / dichloromethane / 1 h / 5 °C / Inert atmosphere

7.1: sodium hydride / n-heptane; ISOPROPYLAMIDE / 7 h / 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 19 h / 20 - 50 °C

With tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; trichlorophosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; n-heptane; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; mineral oil;