4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

Base Information

Chemical Name:4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate
CAS No.:1363374-22-4
Molecular Formula:C₂₄H₂₆FN₃O₇S
Molecular Weight:519.551
Hs Code.:

Synonyms:4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

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Chemical Property of 4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

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Technology Process of 4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

There total 7 articles about 4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1415910-86-9
4-(nitrooxy)butyl N-(tert-butoxycarbonyl)-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)-2-amino-acetate

: 1363374-22-4
4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

Guidance literature:: With trifluoroacetic acid; at 0 - 60 ℃; for 0.666667h; under 8791.75 Torr; Microwave irradiation;
DOI:10.1016/j.ejmech.2012.10.014

Reference yield: 57.0%

: 1363374-22-4
4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

Guidance literature:

Reference yield:

: 2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(fluoro)phenyl]-1H-pyrrole

: 1363374-22-4
4-(nitrooxy)butyl-[2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

Guidance literature:: Multi-step reaction with 7 steps

1: titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium acetate / ethanol; 1,4-dioxane / 40 h / 90 °C

3: zinc; formic acid / ethanol / 0 - 20 °C

4: methanol / 18 h

5: sodium hydroxide; water / methanol / 17 h

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / Inert atmosphere

7: trifluoroacetic acid / 0.67 h / 0 - 60 °C / 8791.75 Torr / Microwave irradiation

With dmap; formic acid; hydroxylamine hydrochloride; water; sodium acetate; titanium tetrachloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; zinc; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2012.10.014