N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid
CAS No.:1415910-82-5
Molecular Formula:C₂₅H₂₇FN₂O₆S
Molecular Weight:502.564
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid

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Chemical Property of N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid

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Technology Process of N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid

There total 8 articles about N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1415910-80-3
C₂₇H₃₁FN₂O₆S

: 1415910-82-5
N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid

Guidance literature:: With water; sodium hydroxide; In methanol; for 17h;
DOI:10.1016/j.ejmech.2012.10.014

Reference yield:

: ethyl 2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

: 1415910-82-5
N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; 1,4-dioxane / 40 h / 90 °C

2: zinc; formic acid / ethanol / 0 - 20 °C

3: methanol / 18 h

4: sodium hydroxide; water / methanol / 17 h

With formic acid; hydroxylamine hydrochloride; water; sodium acetate; sodium hydroxide; zinc; In 1,4-dioxane; methanol; ethanol;
DOI:10.1016/j.ejmech.2012.10.014

Reference yield:

: 1363375-47-6
ethyl 2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetate

: 1415910-82-5
N-(tert-butoxycarbonyl)-2-[1-(3-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 18 h

2: sodium hydroxide; water / methanol / 17 h

With water; sodium hydroxide; In methanol;
DOI:10.1016/j.ejmech.2012.10.014