{3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone

Base Information

• Chemical Name: {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone
• CAS No.: 1488425-86-0
• Molecular Formula: C₂₆H₂₂Cl₂FN₅O
• Molecular Weight: 510.398
• Mol file: 1488425-86-0.mol

Synonyms:{3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone

Chemical Property of {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone

There total 3 articles about {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H10Cl3N3O (1191284-76-0) + 1-(4-Fluorophenyl)piperazine (2252-63-3) → {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone (1488425-86-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.3184/174751913X13734652599909

Reference yield:

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylic acid (1321970-11-9) → {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone (1488425-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4 h / Reflux

2: triethylamine / dichloromethane / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.3184/174751913X13734652599909

Reference yield:

ethyl 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylate → {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone (1488425-86-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 2 h / Reflux

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4 h / Reflux

3: triethylamine / dichloromethane / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In ethanol; dichloromethane;

DOI:10.3184/174751913X13734652599909

upstream raw materials:

C₁₆H₁₀Cl₃N₃O

1-(4-Fluorophenyl)piperazine

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylic acid