N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide

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Chemical Name:N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide
CAS No.:1420468-85-4
Molecular Formula:C₂₂H₂₄F₃N₅O₂
Molecular Weight:447.46
Hs Code.:

Synonyms:N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide

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Chemical Property of N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide

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Technology Process of N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide

There total 13 articles about N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1420468-83-2
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

: 1420468-85-4
N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide

Guidance literature:: With acetic anhydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield: 11.0%

: 1420468-83-2
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

: 108-24-7
acetic anhydride

: 1420468-85-4
N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide

Guidance literature:: In N,N-dimethyl-formamide;
DOI:10.1021/ml300330m

Reference yield:

: 1420468-30-9
2-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-3-oxobutanenitrile

: 1420468-85-4
N-[2-methyl-3-{[2-methyl-3-(trifluoromethyl) phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-yl]acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: hydrazine hydrate / ethanol / 20 - 100 °C / Inert atmosphere

2: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

3: N,N-diethylaniline; trichlorophosphate / 3.25 h / 0 - 80 °C / Inert atmosphere

4: sodium hydroxide / tetrahydrofuran / 3 h / 50 °C

5: ethanol / 3 h / 145 °C / Microwave irradiation

6: N,N-diethylaniline; trichlorophosphate / 0.58 h / 0 - 80 °C / Inert atmosphere

7: ammonia / methanol / 3 h / 0 - 135 °C / Inert atmosphere

8: N,N-dimethyl-formamide

With ammonia; sodium methylate; hydrazine hydrate; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml300330m