C₁₈H₁₀ClF₄NO

Base Information

• Chemical Name: C₁₈H₁₀ClF₄NO
• CAS No.: 1416806-11-5
• Molecular Formula: C₁₈H₁₀ClF₄NO
• Molecular Weight: 367.73
• Mol file: 1416806-11-5.mol

Synonyms:C₁₈H₁₀ClF₄NO

Chemical Property of C₁₈H₁₀ClF₄NO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₀ClF₄NO

There total 10 articles about C₁₈H₁₀ClF₄NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + C17H8ClF4NO (1416806-10-4) → C18H10ClF4NO (1416806-11-5)

Guidance literature:

In diethyl ether; at 0 - 20 ℃; for 4h;

Reference yield:

4-chlorobenzaldehyde (104-88-1) → C18H10ClF4NO (1416806-11-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium cyanide / water; methanol / 20 - 70 °C

2.1: 6 h / 120 °C / Inert atmosphere

3.1: ammonia / dichloromethane; water / 0.5 h / -25 °C / Inert atmosphere

4.1: copper(ll) sulfate pentahydrate / ethanol; water / 0.5 h / Inert atmosphere; Reflux

5.1: trifluoroacetic acid / ethanol / Inert atmosphere; Reflux

6.1: trifluoroacetic acid / dichloromethane / 3 h / Inert atmosphere; Reflux

7.1: sodium nitrite; hydrogen bromide / water / 1.25 h / 0 °C

8.1: bronze powder / dimethyl sulfoxide / 16 h / Inert atmosphere

9.1: n-butyllithium / hexane; diethyl ether / -78 °C / Inert atmosphere

9.2: 1.25 h / -78 - 20 °C / Inert atmosphere

10.1: diethyl ether / 4 h / 0 - 20 °C

With sodium cyanide; bronze powder; n-butyllithium; copper(ll) sulfate pentahydrate; ammonia; hydrogen bromide; trifluoroacetic acid; sodium nitrite; trifluoroacetic acid; In methanol; diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

(4-Chloro-phenyl)-(cyanomethyl-methyl-amino)-acetonitrile (135737-05-2) → C18H10ClF4NO (1416806-11-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 6 h / 120 °C / Inert atmosphere

2.1: ammonia / dichloromethane; water / 0.5 h / -25 °C / Inert atmosphere

3.1: copper(ll) sulfate pentahydrate / ethanol; water / 0.5 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / ethanol / Inert atmosphere; Reflux

5.1: trifluoroacetic acid / dichloromethane / 3 h / Inert atmosphere; Reflux

6.1: sodium nitrite; hydrogen bromide / water / 1.25 h / 0 °C

7.1: bronze powder / dimethyl sulfoxide / 16 h / Inert atmosphere

8.1: n-butyllithium / hexane; diethyl ether / -78 °C / Inert atmosphere

8.2: 1.25 h / -78 - 20 °C / Inert atmosphere

9.1: diethyl ether / 4 h / 0 - 20 °C

With bronze powder; n-butyllithium; copper(ll) sulfate pentahydrate; ammonia; hydrogen bromide; trifluoroacetic acid; sodium nitrite; trifluoroacetic acid; In diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

4-chlorobenzaldehyde

diazomethane

C₁₇H₈ClF₄NO

7-chloroisoquinolin-3-amine

Downstream raw materials:

1-(7-Chloroisoquinolin-3-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Refernces