(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate

Base Information

Chemical Name:(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate
CAS No.:1613271-20-7
Molecular Formula:C₄₉H₆₆O₆SSi
Molecular Weight:811.211
Hs Code.:

(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate

Synonyms:(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate

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Chemical Property of (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate

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Technology Process of (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate

There total 9 articles about (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 1613271-19-4
(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol

: 1613271-20-7
(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1613271-16-1
(3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-3a,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-2(3H)-one

: 1613271-20-7
(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; sodium hydroxide / ethanol; water / 18 h / -10 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 40 h / 50 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

4: triethylamine; dmap / dichloromethane / 15 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; tetrabutyl ammonium fluoride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1613271-15-0
(4R,9aS)-3-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-4-((tert-butyldimethylsilyl)oxy)-8-methoxy-9,9a-dihydro-1H-cyclopenta[b]naphthalen-2(4H)-one

: 1613271-20-7
(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)-2-hydroxybutyl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; 15 wt% palladium on carbon; potassium carbonate / tetrahydrofuran / 517.16 Torr

2: sodium tetrahydroborate; sodium hydroxide / ethanol; water / 18 h / -10 °C / Inert atmosphere

3: 1H-imidazole / N,N-dimethyl-formamide / 40 h / 50 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

5: triethylamine; dmap / dichloromethane / 15 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; 15 wt% palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;