Technology Process of D-3-iodo-4,5-diisopropyloxyphenyl glycine methyl ester
There total 8 articles about D-3-iodo-4,5-diisopropyloxyphenyl glycine methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: aq. NaHCO3; KBr; NaOCl / TEMPO / acetone / 1.5 h / 0 °C
2: SOCl2 / 12 h / 20 °C
With
sodium hypochlorite; thionyl chloride; sodium hydrogencarbonate; potassium bromide;
2,2,6,6-tetramethyl-piperidine-N-oxyl;
In
acetone;
DOI:10.1021/ol070889p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: n-Bu4NF / tetrahydrofuran / 2 h / 0 °C
2: aq. NaHCO3; KBr; NaOCl / TEMPO / acetone / 1.5 h / 0 °C
3: SOCl2 / 12 h / 20 °C
With
sodium hypochlorite; thionyl chloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium bromide;
2,2,6,6-tetramethyl-piperidine-N-oxyl;
In
tetrahydrofuran; acetone;
DOI:10.1021/ol070889p
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: AD-mix-α / 2-methyl-propan-2-ol; H2O / 6 h / 25 °C
1.2: imidazole / dimethylformamide / 5 h / 0 °C
1.3: triphenylphosphine; diisopropyl azodicarboxylate; diphenylphosphoryl azide / tetrahydrofuran / 2 h / 0 °C
2.1: triphenylphosphine / tetrahydrofuran; H2O / 3 h / 60 °C
3.1: Et3N / CH2Cl2 / 20 °C
4.1: n-Bu4NF / tetrahydrofuran / 2 h / 0 °C
5.1: aq. NaHCO3; KBr; NaOCl / TEMPO / acetone / 1.5 h / 0 °C
6.1: SOCl2 / 12 h / 20 °C
With
sodium hypochlorite; AD-mix-α; thionyl chloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; potassium bromide;
2,2,6,6-tetramethyl-piperidine-N-oxyl;
In
tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;
1.1: Sharpless asymmetric dihydroxylation / 1.3: Mitsunobu reaction;
DOI:10.1021/ol070889p
