(2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride

Base Information

Chemical Name:(2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride
CAS No.:579475-21-1
Molecular Formula:C₃₁H₃₅F₇N₄O₂*ClH
Molecular Weight:665.094
Hs Code.:

(2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride

Synonyms:(2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride

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Chemical Property of (2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride

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Technology Process of (2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride

There total 1 articles about (2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 414910-03-5
(2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide

: 151763-88-1
(S)-(-)-hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one

: 579475-21-1
(2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride

: (2R,4S)-4-[(8aR)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride

Guidance literature:: (2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide; (S)-(-)-hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one; With sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃; for 23h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.bmc.2013.09.001

Reference yield:

: 579475-21-1
(2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride

: 110-16-7,26099-09-2
maleic acid

: 579475-24-4
2-(R)-(4-fluoro-2-methylphenyl)-4-(S)-((8aS)-6-oxo-hexahydropyrrolo[1,2-a]pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide maleate

Guidance literature:: (2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride; With ammonia; In water; ethyl acetate;

maleic acid; In 2,2,4-trimethylpentane; isopropyl alcohol; Product distribution / selectivity;