Benzoic acid (1R,3R,6R)-3-benzyloxycarbonylamino-6-chloro-cycloheptyl ester

Base Information

Chemical Name:Benzoic acid (1R,3R,6R)-3-benzyloxycarbonylamino-6-chloro-cycloheptyl ester
CAS No.:95687-97-1
Molecular Formula:C₂₂H₂₄ClNO₄
Molecular Weight:401.89
Hs Code.:

Synonyms:Benzoic acid (1R,3R,6R)-3-benzyloxycarbonylamino-6-chloro-cycloheptyl ester

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Chemical Property of Benzoic acid (1R,3R,6R)-3-benzyloxycarbonylamino-6-chloro-cycloheptyl ester

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Technology Process of Benzoic acid (1R,3R,6R)-3-benzyloxycarbonylamino-6-chloro-cycloheptyl ester

There total 7 articles about Benzoic acid (1R,3R,6R)-3-benzyloxycarbonylamino-6-chloro-cycloheptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 95687-98-2
all-cis-3-(benzoyloxy)-5-(<(benzyloxy)carbonyl>amino)-cycloheptanol

: 95687-97-1
3β-(benzoyloxy)-1β(<(benzyloxy)carbonyl>amino)-5α-chlorocycloheptane

: 95687-99-3
bis(all-cis-3-(benzoyloxy)-5-(<(benzyloxy)-carbonyl>amino)cycloheptyl) sulfite

Guidance literature:: With pyridine; thionyl chloride; In chloroform; for 1h; Heating;
DOI:10.1021/jo00211a006

Reference yield: 36.0%

: 95687-98-2
Benzoic acid (1R,3R,6S)-3-benzyloxycarbonylamino-6-hydroxy-cycloheptyl ester

: 95687-97-1
Benzoic acid (1R,3R,6R)-3-benzyloxycarbonylamino-6-chloro-cycloheptyl ester

: 95687-99-3
C₄₄H₄₈N₂O₁₁S

Guidance literature:: With pyridine; thionyl chloride; In chloroform; at 0 ℃;
DOI:10.1016/S0040-4039(01)91127-X

Reference yield:

: 59171-91-4
cyclohepta-3,5-dien-1-yl benzoate

: 95687-97-1
3β-(benzoyloxy)-1β(<(benzyloxy)carbonyl>amino)-5α-chlorocycloheptane

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / ethanol; CCl₄ / 1.) -20 deg C, 5 h, 2.) -10 deg C, 14 d

2: 98 percent / H₂ / 5percent Pd/C / methanol / 7 h

3: Na₂CO₃ / 1.) chloroform, water, 0 deg C, 30 min, 2.) RT, 2h

4: 36 percent / pyridine, SOCl₂ / CHCl₃ / 1 h / Heating

With pyridine; thionyl chloride; hydrogen; sodium carbonate; palladium on activated charcoal; In methanol; tetrachloromethane; ethanol; chloroform;
DOI:10.1021/jo00211a006