4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Base Information

Chemical Name:4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester
CAS No.:1257235-84-9
Molecular Formula:C₃₂H₄₁F₂N₃O₆
Molecular Weight:601.691
Hs Code.:

4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Synonyms:4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

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Chemical Property of 4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

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Technology Process of 4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

There total 19 articles about 4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 1257235-82-7
3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

: 1257235-84-9
4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃;

Reference yield:

: 850003-05-3
(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester

: 1257235-84-9
4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 16 steps

1: lithium borohydride / tetrahydrofuran / 0 °C

2: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 °C

3: triethylamine

4: thionyl chloride; triethylamine / dichloromethane / -78 °C

5: cerium(III) chloride; sodium iodide / methanol; water; acetonitrile / 20 - 40 °C

6: hydrogen / Raney Ni / ethanol; water / 1.5 h / 2585.81 Torr

7: triethylamine / dichloromethane / 0 - 20 °C

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

9: dmap / dichloromethane / 0 °C

10: sodium hydride / N,N-dimethyl-formamide / 0 °C

11: sodium periodate / ruthenium trichloride / 1-methyl-pyrrolidin-2-one; tetrachloromethane; water; acetonitrile

12: diethyl ether

13: lithium borohydride / tetrahydrofuran / 0 °C

14: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 20 °C

15: trifluoroacetic acid / dichloromethane / 0 °C

16: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

With sodium periodate; lithium borohydride; thionyl chloride; cerium(III) chloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sulfur trioxide pyridine complex; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; sodium iodide; dmap; ruthenium trichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; benzene;

Reference yield:

: 757247-71-5
tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate

: 1257235-84-9
4-(2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-3-(3,4-difluorophenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 14 steps

1: triethylamine

2: thionyl chloride; triethylamine / dichloromethane / -78 °C

3: cerium(III) chloride; sodium iodide / methanol; water; acetonitrile / 20 - 40 °C

4: hydrogen / Raney Ni / ethanol; water / 1.5 h / 2585.81 Torr

5: triethylamine / dichloromethane / 0 - 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

7: dmap / dichloromethane / 0 °C

8: sodium hydride / N,N-dimethyl-formamide / 0 °C

9: sodium periodate / ruthenium trichloride / 1-methyl-pyrrolidin-2-one; tetrachloromethane; water; acetonitrile

10: diethyl ether

11: lithium borohydride / tetrahydrofuran / 0 °C

12: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 20 °C

13: trifluoroacetic acid / dichloromethane / 0 °C

14: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

With sodium periodate; lithium borohydride; thionyl chloride; cerium(III) chloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; sodium iodide; dmap; ruthenium trichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;