7-bromo-1-(4-methoxybenzyl)-4,5-dihydro-1H-benzo[g]indazole

Base Information

• Chemical Name: 7-bromo-1-(4-methoxybenzyl)-4,5-dihydro-1H-benzo[g]indazole
• CAS No.: 1251931-34-6
• Molecular Formula: C₁₉H₁₇BrN₂O
• Molecular Weight: 369.261
• Mol file: 1251931-34-6.mol

Synonyms:7-bromo-1-(4-methoxybenzyl)-4,5-dihydro-1H-benzo[g]indazole

Chemical Property of 7-bromo-1-(4-methoxybenzyl)-4,5-dihydro-1H-benzo[g]indazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-bromo-1-(4-methoxybenzyl)-4,5-dihydro-1H-benzo[g]indazole

There total 1 articles about 7-bromo-1-(4-methoxybenzyl)-4,5-dihydro-1H-benzo[g]indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

7-bromo-4,5-dihydro-1H-benzo[g]indazole (1251931-33-5) + p-methoxybenzyl chloride (824-94-2) → 7-bromo-1-(4-methoxybenzyl)-4,5-dihydro-1H-benzo[g]indazole (1251931-34-6)

Guidance literature:

7-bromo-4,5-dihydro-1H-benzo[g]indazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

DOI:10.1016/j.bmc.2010.06.031

Reference yield:

7-bromo-1-(4-methoxybenzyl)-4,5-dihydro-1H-benzo[g]indazole (1251931-34-6) + bis(pinacol)diborane (73183-34-3) → 1-(4-methoxybenzyl)-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-4,5-dihydro-1H-benzo[g]indazole (1251931-35-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1016/j.bmc.2010.06.031

upstream raw materials:

7-bromo-4,5-dihydro-1H-benzo[g]indazole

p-methoxybenzyl chloride

Downstream raw materials:

1-(4-methoxybenzyl)-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-4,5-dihydro-1H-benzo[g]indazole