(1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

Base Information

Chemical Name:(1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester
CAS No.:714959-70-3
Molecular Formula:C₁₆H₁₉Cl₅NO₆P
Molecular Weight:529.569
Hs Code.:

Synonyms:(1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

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Chemical Property of (1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

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Technology Process of (1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

There total 3 articles about (1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 91077-75-7
α-Trimethylsilyloxy-3,4-dichlorostyrene

: {[(E)-2,2,2-Trichloro-ethoxycarbonylimino]-methyl}-phosphonic acid diethyl ester

: 714959-70-3
(1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; C₃₈H₃₂CuF₆N₂O₄S₂; In dichloromethane; at 0 ℃; for 9h; Molecular sieve 3A;

Reference yield:

: 108217-08-9
[bromo-(2,2,2-trichloroethoxycarbonylamino)methyl]phosphonic acid diethyl ester

: 714959-70-3
(1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidinomethylpolystyrene; 4A molecular sieves / CH₂Cl₂ / 0.33 h / 20 °C

2: hexafluoroisopropyl alcohol; (R,R)-N,N'-(1-naphthylmethyl)-1,2-diphenylethane-1,2-diamine; 3A molecular sieves / Cu(OTf)2 / CH₂Cl₂ / 9 h

With (1R,2R)-N,N’-bis(naphthalen-1-ylmethyl)-1,2-diphenylethane-1,2-diamine; piperidinomethylpolystyrene; 1,1,1,3',3',3'-hexafluoro-propanol; 3 A molecular sieve; 4 A molecular sieve; copper(II) bis(trifluoromethanesulfonate); In dichloromethane;
DOI:10.1021/ja048791i

Reference yield:

: 91077-75-7
α-Trimethylsilyloxy-3,4-dichlorostyrene

: {[(E)-2,2,2-Trichloro-ethoxycarbonylimino]-methyl}-phosphonic acid diethyl ester

: 714959-70-3
(1S)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

: (1R)-[3-oxo-3-(3,4-dichlorophenyl)-1-(2,2,2-trichloroethoxycarbonylamino)propyl]phosphonic acid diethyl ester

Guidance literature:: With (1R,2R)-N,N’-bis(naphthalen-1-ylmethyl)-1,2-diphenylethane-1,2-diamine; 1,1,1,3',3',3'-hexafluoro-propanol; 3 A molecular sieve; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; for 9h; Title compound not separated from byproducts;
DOI:10.1021/ja048791i