91077-75-7Relevant academic research and scientific papers
Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes
Chen, Yuehua,Deng, Hao,Gao, Xing,Guo, Hongchao,Jiang, Feng,Wang, Wei,Wu, Yongjun,Zhu, Dongyu
supporting information, p. 7158 - 7163 (2020/10/02)
A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon-carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy scalability and versatile transformability of the reaction products were also exhibited.
A Topliss tree analysis of the HIV-protease inhibitory activity of 6- phenyl-4-hydroxy-pyran-2-ones
Steinbaugh,Hamilton,Prasad,Para,Tummino,Ferguson,Lunney,Blankley
, p. 1099 - 1104 (2007/10/03)
In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substituents were made.
SILICON-CONTAINING NUCLEOPHILES IN C- AND N-AMIDOMETHYLATION REACTIONS WITH THE PARTICIPATION OF 5-OXAZOLIDINONES
Shipov, A. G.,Orlova, N. A.,Savostyanova, I. A.,Artamkina, O. B.,Baukov, Yu. I.
, p. 959 - 971 (2007/10/02)
1.Silicon-containing C- and N-nucleophiles (O-silyl-substituted enols, allyl- and cyanotrimethylsilane, N-trimethylsilyl derivatives of amides, lactams, imides, sulfonamides, pyrazoles, and imidazole) on reaction with 5-oxazolidinone in the presence of tr
