2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester

Base Information

• Chemical Name: 2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester
• CAS No.: 1041479-83-7
• Molecular Formula: C₂₈H₃₇ClO₃S
• Molecular Weight: 489.119
• Mol file: 1041479-83-7.mol

Synonyms:2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester

Chemical Property of 2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester

There total 1 articles about 2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-phenylbutanoate (16537-11-4) + [chloro-(p-tolylsulfinyl)methylidene]cyclohexane (644977-16-2) → 2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester (1041479-83-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

DOI:10.1016/j.tet.2008.04.024

Reference yield: 92.0%

2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester (1041479-83-7) → tert-butyl 2-[1-(chloromethyl)cyclohexyl]-4-phenylbutanoate

Guidance literature:

2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester; With isopropylmagnesium chloride; In tetrahydrofuran; at -60 ℃; for 0.0833333h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; Saturated solution;

DOI:10.1055/s-0032-1318168

Reference yield: 89.0%

2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester (1041479-83-7) → 2-bicyclo[4.1.0]hept-1-yl-4-phenylbutyric acid tert-butyl ester (1041479-85-9)

Guidance literature:

With isopropylmagnesium chloride; In diethyl ether; toluene; at -78 - 0 ℃; for 2h;

DOI:10.1016/j.tet.2008.04.024

upstream raw materials:

tert-butyl 4-phenylbutanoate

[chloro-(p-tolylsulfinyl)methylidene]cyclohexane

Downstream raw materials:

2-bicyclo[4.1.0]hept-1-yl-4-phenylbutyric acid tert-butyl ester