644977-16-2

Basic information

• Product Name: [chloro-(p-tolylsulfinyl)methylidene]cyclohexane
• Synonyms: [chloro-(p-tolylsulfinyl)methylidene]cyclohexane
• CAS NO: 644977-16-2
• Molecular Weight: 268.807
• Mol File: 644977-16-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [chloro-(p-tolylsulfinyl)methylidene]cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: [chloro-(p-tolylsulfinyl)methylidene]cyclohexane(644977-16-2)
• EPA Substance Registry System: [chloro-(p-tolylsulfinyl)methylidene]cyclohexane(644977-16-2)

Safety Data

• Hazardous Substances Data: 644977-16-2(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 24824-93-9 chloromethyl p-tolyl sulfoxide 
• 644977-14-0 acetic acid 1-[chloro-(toluene-4-sulfinyl)methyl]cyclohexyl ester 

Downstream Products

• 18138-88-0 2-(cyclohexylidenemethyl)furan 
• 1303963-17-8 1-[chloro(p-tolylsulfinyl)methyl]-1-(phenylethynyl)cyclohexane 
• 1303963-17-8 1-[chloro(p-tolylsulfinyl)methyl]-1-(phenylethynyl)cyclohexane 
• 1303963-17-8 1-[chloro(p-tolylsulfinyl)methyl]-1-(phenylethynyl)cyclohexane 
• 1041479-83-7 2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-4-phenylbutyric acid tert-butyl ester 
• 913366-52-6 2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}hexanoic acid tert-butyl ester 
• 1041480-00-5 2-{1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}-N,N-dimethylacetamide 
• 913366-44-6 {1-[chloro(p-tolylsulfinyl)methyl]cyclohexyl}acetic acid tert-butyl ester 

Relevant articles and documents

Efficient one-pot synthesis of 1-chlorovinyl p-tolyl sulfoxides from aldehydes and ketones by the Horner-Wadsworth-Emmons reaction

A variety of 2-monosubstituted and 2,2-disubstituted 1-chlorovinyl p-tolyl sulfoxides was synthesized through a one-pot procedure by the Horner-Wadsworth-Emmons reaction of carbonyl compounds with [chloro(diethoxyphosphoryl)(p-tolylsulfinyl)methyl]lithium, which was generated from diethyl chlorophosphate, chloromethyl p-tolyl sulfoxide, and lithium diisopropylamide in advance. The in situ-prepared sulfoxides were directly converted into alkynes via the sulfoxide/magnesium exchange reaction with i-PrMgCl and the subsequent Fritsch-Buttenberg-Wiechell rearrangement of the resulting magnesium alkylidene carbenoids.