(thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone

Base Information

• Chemical Name: (thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone
• CAS No.: 675860-72-7
• Molecular Formula: C₁₆H₁₈N₂O₂S
• Molecular Weight: 302.397
• Mol file: 675860-72-7.mol

Synonyms:(thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone

Chemical Property of (thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone

There total 3 articles about (thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Thiophenecarbonyl chloride (5271-67-0) + 1-(para-methoxyphenyl)piperazine hydrochloride (84145-43-7,70849-64-8) → (thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone (675860-72-7)

Guidance literature:

With TEA; In chloroform; for 8h; Reflux;

DOI:10.2174/1573406409666131128144755

Reference yield:

4-methoxy-aniline (104-94-9) → (thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone (675860-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: butan-1-ol / 10 h / Reflux

1.2: 48 h

2.1: TEA / chloroform / 8 h / Reflux

With TEA; In chloroform; butan-1-ol;

DOI:10.2174/1573406409666131128144755

Reference yield:

2-thiophenylcarboxylic acid (527-72-0) → (thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone (675860-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / chloroform / 1 h / Reflux

2: TEA / chloroform / 8 h / Reflux

With thionyl chloride; In chloroform;

DOI:10.2174/1573406409666131128144755

upstream raw materials:

2-thiophenylcarboxylic acid

2-Thiophenecarbonyl chloride

1-(para-methoxyphenyl)piperazine hydrochloride

4-methoxy-aniline