2-<<7-(4-chlorobenzoyl)-1H-indol-3-yl>methyl>propanedioic acid, diethyl ester

Base Information

Chemical Name:2-<<7-(4-chlorobenzoyl)-1H-indol-3-yl>methyl>propanedioic acid, diethyl ester
CAS No.:116764-12-6
Molecular Formula:C₂₃H₂₂ClNO₅
Molecular Weight:427.884
Hs Code.:

Synonyms:2-<<7-(4-chlorobenzoyl)-1H-indol-3-yl>methyl>propanedioic acid, diethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-<<7-(4-chlorobenzoyl)-1H-indol-3-yl>methyl>propanedioic acid, diethyl ester

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Technology Process of 2-<<7-(4-chlorobenzoyl)-1H-indol-3-yl>methyl>propanedioic acid, diethyl ester

There total 2 articles about 2-<<7-(4-chlorobenzoyl)-1H-indol-3-yl>methyl>propanedioic acid, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 116764-11-5
(4-chlorophenyl)<3-<(dimethylamino)methyl>-1H-indol-7-yl>methanone

: 105-53-3
diethyl malonate

: 116764-12-6
2-<<7-(4-chlorobenzoyl)-1H-indol-3-yl>methyl>propanedioic acid, diethyl ester

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; for 17h; Heating;
DOI:10.1021/jm00170a039

Reference yield:

: 91714-48-6
(4-chlorophenyl)(1H-indol-7-yl)methanone

: 116764-12-6
2-<<7-(4-chlorobenzoyl)-1H-indol-3-yl>methyl>propanedioic acid, diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / glacial CH₃CO₂H / ethanol; H₂O / 0.5 h

2: 67 percent / NaH / dimethylsulfoxide / 17 h / Heating

With sodium hydride; acetic acid; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00170a039