1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine

Base Information

• Chemical Name: 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine
• CAS No.: 97626-18-1
• Molecular Formula: C₂₂H₄₀N₂O₆Si₂
• Molecular Weight: 484.74
• Mol file: 97626-18-1.mol

Synonyms:1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine

Chemical Property of 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine

There total 2 articles about 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine (97626-18-1)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1002/cbdv.201100338

Reference yield: 96.6%

→ 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine (97626-18-1)

Guidance literature:

Reference yield: 69.0%

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) + 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine (97626-18-1) → 4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)thymidine (342630-75-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1055/s-2001-12355

upstream raw materials:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

thymidine

Downstream raw materials:

4-O-[(2,4,6-Triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)thymidine

5'-O-(4,4'-Dimethoxytrityl)-5-methyl-N⁴-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine

N¹-(β-D-2'-deoxyribosyl)-5-methylpyrimidin-2-one