ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS No.: 326870-62-6
• Molecular Formula: C₁₄H₁₆N₂O₄S
• Molecular Weight: 308.358
• Mol file: 326870-62-6.mol

Synonyms:ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property of ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 1 articles about ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl acetoacetate (141-97-9) + thiourea (17356-08-0) + 3,4-dihydroxybenzaldehyde (139-85-5) → ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (326870-62-6)

Guidance literature:

With nanometasilica disulfuric acid; In neat (no solvent); at 80 ℃; for 0.25h; Reagent/catalyst; Green chemistry;

DOI:10.1007/s13738-016-0964-1

Reference yield:

ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (326870-62-6) + chloroacetic acid ethyl ester (105-39-5) → C16H16N2O5S (1163296-99-8)

Guidance literature:

With pyridine; In ethanol; at 78 ℃; for 3h;

DOI:10.1002/cmdc.201700175

Reference yield:

ethyl 4-(3,4-dihydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (326870-62-6) → ethyl (Z)-5-(3,4-dihydroxyphenyl)-7-methyl-2-(4-morpholinobenzylidene)-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / ethanol / 3 h / 78 °C

2: morpholine / ethanol / 6 h / 78 °C

With morpholine; pyridine; In ethanol; 2: |Knoevenagel Condensation;

DOI:10.1002/cmdc.201700175

upstream raw materials:

ethyl acetoacetate

thiourea

3,4-dihydroxybenzaldehyde

Downstream raw materials:

C₁₆H₁₆N₂O₅S