(E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide

Base Information

• Chemical Name: (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide
• CAS No.: 1367349-47-0
• Molecular Formula: C₂₅H₂₂FNO₄
• Molecular Weight: 419.452

Synonyms:(E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide

Chemical Property of (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide

Chemical Property:

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Technology Process of (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide

There total 2 articles about (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoroboronic acid (1765-93-1) → (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide (1367349-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 0.33 h / 150 °C / Microwave irradiation

2: potassium hydroxide / ethanol / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; potassium hydroxide; In 1,4-dioxane; ethanol; water; 1: Suzuki-Miyaura coupling / 2: Knoevenagel condensation;

DOI:10.1016/j.ejmech.2012.02.023

Reference yield:

4-acetamido-3-bromoacetophenone (101209-08-9) → (E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide (1367349-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 0.33 h / 150 °C / Microwave irradiation

2: potassium hydroxide / ethanol / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; potassium hydroxide; In 1,4-dioxane; ethanol; water; 1: Suzuki-Miyaura coupling / 2: Knoevenagel condensation;

DOI:10.1016/j.ejmech.2012.02.023

Reference yield: 62.35%

(E)-N-(5-(3-(3,4-dimethoxyphenyl)acryloyl)-4'-fluoro-[1,1'-biphenyl]-2-yl)acetamide (1367349-47-0) → (E)-1-(6-amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one (1367349-48-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 70 ℃; for 8h;

DOI:10.1016/j.ejmech.2012.02.023

upstream raw materials:

4-fluoroboronic acid

4-acetamido-3-bromoacetophenone

Downstream raw materials:

(E)-1-(6-amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one

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