101209-08-9

Basic information

• Product Name: 4-Acetamido-3-bromoacetophenone
• Synonyms: 4-ACETAMIDO-3-BROMOACETOPHENONE;LABOTEST-BB LT00455487;4-Acetyl-2-bromoacetanilide~2-Bromo-N,4-diacetylaniline;4-Acetyl-2-bromoacetanilide;2-bromo-n,4-diacetylaniline;N-(4-acetyl-2-bromophenyl)acetamide
• CAS NO: 101209-08-9
• Molecular Formula: C₁₀H₁₀BrNO₂
• Molecular Weight: 256.1
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);C10;Carbonyl Compounds;Ketones
• Mol File: 101209-08-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 139-141°C
• Boiling Point: 436.1 °C at 760 mmHg
• Flash Point: 217.5 °C
• Appearance: /
• Density: 1.504g/cm³
• Vapor Pressure: 8.32E-08mmHg at 25°C
• Refractive Index: 1.6
• PKA: 13.66±0.70(Predicted)
• BRN: 3272108
• CAS DataBase Reference: 4-Acetamido-3-bromoacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetamido-3-bromoacetophenone(101209-08-9)
• EPA Substance Registry System: 4-Acetamido-3-bromoacetophenone(101209-08-9)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 22-24/25-45
• RIDADR: UN 2811
• WGK Germany: 3
• Hazardous Substances Data: 101209-08-9(Hazardous Substances Data)

Usage

General Description

4-Acetamido-3-bromoacetophenone is a chemical compound with the molecular formula C10H10BrNO2. It is a bromoacetophenone derivative and is commonly used in the synthesis of various pharmaceuticals and organic compounds. The compound has a yellowish to brownish appearance and is primarily used as an intermediate in the production of other chemicals. It is a valuable building block in organic synthesis and can be utilized in the preparation of a wide range of molecules with diverse biological activities. Furthermore, 4-Acetamido-3-bromoacetophenone has potential applications in medicinal chemistry and drug discovery due to its versatile reactivity and structural features.

InChI:InChI=1/C10H10BrNO2/c1-6(13)8-3-4-10(9(11)5-8)12-7(2)14/h3-5H,1-2H3,(H,12,14)

Upstream product

• 2719-21-3 4-(N-acetylamino)acetophenone 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 103-89-9 4-Methylacetanilide 

Downstream Products

• 93273-64-4 4-acetyl-2-bromobenzoic acid 
• 93273-63-3 4-acetyl-2-bromobenzonitrile 
• 1100768-15-7 N-(1-{3-bromo-4-[(piperidine-4-carbonyl)-amino]-phenyl}-ethyl)-N'-(4-carbamimidoyl-phenyl)-malonamide trifluoroacetate 
• 1100768-32-8 N-{1-[3-bromo-4-(morpholine-4-carbonyl)-phenyl]-ethyl}-N'-(4-carbamimidoyl-phenyl)-malonamide trifluoroacetate 
• 1100768-17-9 4-[4-(1-amino-ethyl)-2-bromo-phenylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1100768-33-9 1-[3-bromo-4-(morpholine-4-carbonyl)-phenyl]-ethanone 
• 1100768-34-0 [4-(1-amino-ethyl)-2-bromo-phenyl]-morpholin-4-yl-methanone 
• 1367349-48-1 (E)-1-(6-amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one 
• 1367349-62-9 (E)-1-(6-amino-3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1367349-61-8 (E)-1-(6-amino-3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)-3-(2,3-dimethoxyphenyl)prop-2-en-1-one 
• 1367349-60-7 (E)-1-(6-amino-3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)-3-(2,5-dimethoxyphenyl)prop-2-en-1-one 
• 1367349-59-4 (E)-1-(6-amino-3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one 
• 1367349-58-3 (E)-1-(6-amino-3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)-3-(4-fluorophenyl)prop-2-en-1-one 
• 1367349-56-1 (E)-1-(6-amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Palladium-catalyzed ortho-halogenations of acetanilides with N-halosuccinimides via direct sp2 C–H bond activation in ball mills

A solvent-free palladium-catalyzed ortho-iodination of acetanilides using N-iodosuccinimide as the iodine source has been developed under ball-milling conditions. This present method avoids the use of hazardous organic solvents, high reaction temperature,