(S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Base Information

Chemical Name:(S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453847-93-2
Molecular Formula:C₂₂H₂₂F₂N₄O₃
Molecular Weight:428.438
Hs Code.:

Synonyms:(S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of (S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of (S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 5 articles about (S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1453853-00-3
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(2,3-difluorophenyl)ethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453847-93-2
(S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.333333h;

Reference yield:

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 1453847-93-2
(S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; iso-butanol / 100 °C / Microwave irradiation; Sealed tube

3.1: hydrogenchloride / water / Reflux

4.1: tetra-(n-butyl)ammonium iodide; potassium tert-butylate / 1,4-dioxane; tetrahydrofuran / 0.17 h / Sealed tube

4.2: 95 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium tert-butylate; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium carbonate; N-ethyl-N,N-diisopropylamine; iso-butanol; In tetrahydrofuran; 1,4-dioxane; water; 1.1: |Suzuki Coupling;

Reference yield:

: 361147-25-3
2-chloro-4-(2-fluoropyridin-4-yl)pyrimidine

: 1453847-93-2
(S)-1-(1-(2,3-difluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; iso-butanol / 100 °C / Microwave irradiation; Sealed tube

2.1: hydrogenchloride / water / Reflux

3.1: tetra-(n-butyl)ammonium iodide; potassium tert-butylate / 1,4-dioxane; tetrahydrofuran / 0.17 h / Sealed tube

3.2: 95 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

With hydrogenchloride; potassium tert-butylate; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; iso-butanol; In tetrahydrofuran; 1,4-dioxane; water;