361147-25-3

Basic information

• Product Name: 2-CHLORO-4-(2-FLUOROPYRIDIN-4-YL)PYRIMIDINE
• Synonyms: 2-CHLORO-4-(2-FLUOROPYRIDIN-4-YL)PYRIMIDINE;PyriMidine,2-chloro-4-(2-fluoro-4-pyridinyl)-;2-chloro-4-(2-fluoro-4-pyridinyl)Pyrimidine
• CAS NO: 361147-25-3
• Molecular Formula: C₉H₅ClFN₃
• Molecular Weight: 209.61
• Mol File: 361147-25-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 157-159 °C
• Boiling Point: 394.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.392±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -4.53±0.31(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-(2-FLUOROPYRIDIN-4-YL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-(2-FLUOROPYRIDIN-4-YL)PYRIMIDINE(361147-25-3)
• EPA Substance Registry System: 2-CHLORO-4-(2-FLUOROPYRIDIN-4-YL)PYRIMIDINE(361147-25-3)

Safety Data

• Hazardous Substances Data: 361147-25-3(Hazardous Substances Data)

Usage

General Description

2-CHLORO-4-(2-FLUOROPYRIDIN-4-YL)PYRIMIDINE is a chemical compound with the molecular formula C9H5ClFN3. It is a pyrimidine derivative that contains a chloro substituent at position 2 and a 2-fluoropyridin-4-yl substituent at position 4. 2-CHLORO-4-(2-FLUOROPYRIDIN-4-YL)PYRIMIDINE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of various organic compounds and materials in the chemical industry. 2-CHLORO-4-(2-FLUOROPYRIDIN-4-YL)PYRIMIDINE has a wide range of applications due to its versatile reactivity and structural features.

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 22282-70-8 2-fluoro-4-iodopyridine 
• 1193-21-1 4,6-dichloropyrimidine 
• 128071-98-7 4-bromo-2-fluoropyridine 
• 401815-98-3 2-fluoropyridin-4-ylboronic acid 

Downstream Products

• 1083182-44-8 [3-allyloxymethyl-4-(2-pyrrolidin-1-ylethoxy)phenyl]-[4-(2-fluoropyridin-4-yl)pyrimidin-2-yl]amine 

Relevant articles and documents

Synthesis of Pyridinyl-Pyrimidines via Pd-Catalyzed Cross-Coupling Reactions: A Comparison of Classical Thermal and Microwave Assisted Reaction Conditions

The Negishi cross-coupling reaction was used for the synthesis of pyridinyl-pyrimidines utilizing classical thermal or microwave assisted conditions. The organozinc substrates were prepared from 2-fluoro-4-iodopyridine by conventional lithiation chemistry and subsequent transmetalation with ZnCl2 or ZnI2. Two different catalysts - Pd(PPh3)4 and Pd/C - were investigated for their ability to facilitate the cross coupling process with 2,4-dichloropyrimidine. We found that distribution and yield of desired compounds and possible by-products highly depend on the type of energy input. In contrast to thermal conditions, the microwave assisted method allowed efficient access to di-coupled compounds.

Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2

Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, (S)-14k was selected for further preclinical evaluation.

Discovery of the macrocycle (9 E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25- trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9, 14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of Janus kinase 2/Fms-liketyrosine kinase-3 (J

Herein, we describe the synthesis and SAR of a series of small molecule macrocycles that selectively inhibit JAK2 kinase within the JAK family and FLT3 kinase. Following a multiparameter optimization of a key aryl ring of the previously described SB1518 (