8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne

Base Information

• Chemical Name: 8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne
• CAS No.: 916484-43-0
• Molecular Formula: C₃₃H₄₄OSi₂
• Molecular Weight: 512.883
• Mol file: 916484-43-0.mol

Synonyms:8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne

Chemical Property of 8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne

There total 6 articles about 8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

7-(tert-butyldiphenylsilanyloxy)-3-(dibromomethylidene)-1-triisopropylsilanylhepta-1,4-diyne (916484-41-8) → 8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne (916484-43-0)

Guidance literature:

With n-butyllithium; In hexane; at -78 - 10 ℃;

DOI:10.1021/jo061588g

Reference yield:

7-(tert-butyl-diphenyl-silanyloxy)-1-triisopropylsilanyl-hepta-1,4-diyn-3-one → 8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne (916484-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: PPh₃ / CH₂Cl₂ / 0.5 h / 0 °C

1.2: 874 mg / CH₂Cl₂ / 0.5 h / -20 °C

2.1: 56 percent / BuLi / hexane / -78 - 10 °C

With n-butyllithium; triphenylphosphine; In hexane; dichloromethane; 2.1: Fritsch-Buttenberg-Wiechell rearrangement;

DOI:10.1021/jo061588g

Reference yield:

7-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanylhepta-1,4-diyn-3-ol (916484-39-4) → 8-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanyl-1,3,5-octatriyne (916484-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BaMnO₄ / CH₂Cl₂ / 20 °C

2.1: PPh₃ / CH₂Cl₂ / 0.5 h / 0 °C

2.2: 874 mg / CH₂Cl₂ / 0.5 h / -20 °C

3.1: 56 percent / BuLi / hexane / -78 - 10 °C

With n-butyllithium; barium permanganate; triphenylphosphine; In hexane; dichloromethane; 3.1: Fritsch-Buttenberg-Wiechell rearrangement;

DOI:10.1021/jo061588g

upstream raw materials:

7-(tert-butyldiphenylsilanyloxy)-3-(dibromomethylidene)-1-triisopropylsilanylhepta-1,4-diyne

7-(tert-butyldiphenylsilanyloxy)-1-triisopropylsilanylhepta-1,4-diyn-3-ol

4-(tert-butyldiphenylsilyloxy)-1-butyne

5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-yn-1-ol

Downstream raw materials:

3,5,7-octatriyn-1-ol

Refernces