Technology Process of benzyl (E)-3-[8-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl]acrylate
There total 4 articles about benzyl (E)-3-[8-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl]acrylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; P(tolyl)3; N-ethyl-N,N-diisopropylamine;
In
various solvent(s);
for 18h;
Heating;
DOI:10.1021/jm0204035
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / LiHMDS / tetrahydrofuran / 0.5 h / 0 °C
2: 98 percent / NBS; AcOH / CH2Cl2 / 72 h
3: 54 percent / Pd(OAc)2; P(tolyl)3; i-Pr2NEt / various solvent(s) / 18 h / Heating
With
palladium diacetate; N-Bromosuccinimide; P(tolyl)3; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
3: Heck coupling;
DOI:10.1021/jm0204035
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / LiHMDS / tetrahydrofuran / 0.5 h / 0 °C
2: 98 percent / NBS; AcOH / CH2Cl2 / 72 h
3: 54 percent / Pd(OAc)2; P(tolyl)3; i-Pr2NEt / various solvent(s) / 18 h / Heating
With
palladium diacetate; N-Bromosuccinimide; P(tolyl)3; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
3: Heck coupling;
DOI:10.1021/jm0204035