5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine
CAS No.:511545-98-5
Molecular Formula:C₄₀H₄₉N₄O₈P
Molecular Weight:745.817
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine

Suppliers and Price of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine

There total 6 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 511546-02-4
1-(2'-deoxy-3'-deutero-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl)thymine

: 511545-98-5
5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 0.333333h;
DOI:10.1021/ol034102g

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 511545-98-5
5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 3 Angstroem MS; pyridinium dichromate / CH₂Cl₂ / 20 °C

2: 85 percent / NaB(OAc)3D / acetic acid / 16 h / 20 °C

3: 95 percent / pyridine / 3 h / 20 °C

4: 82 percent / i-Pr₂NEt / CH₂Cl₂ / 0.33 h / 23 °C

With dipyridinium dichromate; 3 Angstroem MS; N-ethyl-N,N-diisopropylamine; sodium triacetoxyborodeuteride; In pyridine; dichloromethane; acetic acid;
DOI:10.1021/ol034102g

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 511545-98-5
5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / pyridine / 3 h / 20 °C

2: 82 percent / i-Pr₂NEt / CH₂Cl₂ / 0.33 h / 23 °C

With N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1021/ol034102g