1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone

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Chemical Name:1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone
CAS No.:1201789-98-1
Molecular Formula:C₂₇H₂₄N₆O
Molecular Weight:448.527
Hs Code.:

Synonyms:1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone

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Chemical Property of 1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone

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Technology Process of 1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone

There total 5 articles about 1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 3-[3-(piperazin-1-yl)phenyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine hydrochloride

: 75-36-5
acetyl chloride

: 1201789-98-1
1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone

Guidance literature:: 3-[3-(piperazin-1-yl)phenyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 0.25h;

acetyl chloride; In dichloromethane; at 25 ℃; for 1.25h;

With water; lithium hydroxide; In methanol; for 0.5h;

Reference yield:

: 1201786-75-5
C₁₅H₁₁ClN₄

: 1201789-98-1
1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / palladium diacetate; (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / 1,4-dioxane / 100 °C / Inert atmosphere

2.1: bromine; acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 7 h / 110 °C / Inert atmosphere; Sealed tube

4.1: hydrogenchloride / methanol / 5 h / 55 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 25 °C

5.2: 1.25 h / 25 °C

5.3: 0.5 h

With hydrogenchloride; potassium tert-butylate; bromine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Hartwig-Buchwald reaction;

Reference yield:

: 1201786-83-5
6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201789-98-1
1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine; acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 7 h / 110 °C / Inert atmosphere; Sealed tube

3.1: hydrogenchloride / methanol / 5 h / 55 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 25 °C

4.2: 1.25 h / 25 °C

4.3: 0.5 h

With hydrogenchloride; bromine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;