7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

Base Information

Chemical Name:7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester
CAS No.:1392839-26-7
Molecular Formula:C₂₂H₁₆FN₃O₄
Molecular Weight:405.385
Hs Code.:

Synonyms:7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

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Chemical Property of 7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

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Technology Process of 7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

There total 8 articles about 7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872041-86-6
5-fluoropyridine-3-boronic acid

: 1392839-23-4
7-benzyl-4-hydroxy-1-iodo-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 1392839-26-7
7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 174740-67-1
dimethyl <2-(ethoxycarbonyl)ethylidene>malonate

: 1392839-26-7
7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 3 h / 80 °C

2.1: ethanol / 5 h / Reflux

3.1: pyridine; lithium iodide / 1 h / Reflux

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

4.2: 16 h / 20 °C

4.3: 16 h / 20 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium methylate / methanol

6.2: pH 4

7.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

8.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; caesium carbonate; sodium iodide; lithium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 33707-28-7
1-benzyl-2-oxo-1,2-dihydro-pyridine-3,4-dicarboxylic acid 4-ethyl ester

: 1392839-26-7
7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

1.2: 16 h / 20 °C

1.3: 16 h / 20 °C

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium methylate / methanol

3.2: pH 4

4.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

5.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

With oxalyl dichloride; sodium methylate; potassium carbonate; caesium carbonate; sodium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide;