3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid

Base Information

Chemical Name:3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid
CAS No.:1392842-20-4
Molecular Formula:C₂₄H₁₉FN₄O₅
Molecular Weight:462.437
Hs Code.:

Synonyms:3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid

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Chemical Property of 3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid

Chemical Property:

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Technology Process of 3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid

There total 20 articles about 3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392839-26-7
7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 107-95-9
3-amino propanoic acid

: 1392842-20-4
3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid

Guidance literature:: With sodium methylate; In methanol; for 16h; Reflux;

Reference yield:

: 1392842-07-7
1-benzyl-5-cyano-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carboxylic acidmethyl amide

: 56-40-6,18875-39-3,25718-94-9
glycine

: 1392842-20-4
3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid

Guidance literature:: With sodium methylate; In methanol; for 16h; Reflux;

Reference yield:

: 58997-10-7
ethyl 3-methylpyridine-2-carboxylate

: 1392842-20-4
3-{[7-benzyl-1-(5-fluoro-pyridin-3-yl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 0 °C / Cooling with ice

3: dichloro-acetic acid / water / 1 h / Reflux

4: potassium carbonate; lithium bromide; tetrabutylammomium bromide / toluene; water / 0.67 h / 80 °C

5: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

6: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

7: sodium methylate / methanol / Cooling with ice

8: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

9: N,N-dimethyl-formamide / 0.13 h / 120 °C

10: ethanol; tetrahydrofuran / 16 h / 80 °C / sealed tube

11: sodium methylate / methanol / 16 h / Reflux

With dichloro-acetic acid; N-Bromosuccinimide; tetrabutylammomium bromide; sodium methylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; lithium bromide; trichlorophosphate; dibenzoyl peroxide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;