ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

Base Information

• Chemical Name: ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate
• CAS No.: 1157864-92-0
• Molecular Formula: C₁₂H₁₀F₄O₃
• Molecular Weight: 278.203
• Mol file: 1157864-92-0.mol

Synonyms:ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

Chemical Property of ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

There total 5 articles about ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 2-fluoro-3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate → ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate (1157864-92-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; water; at 20 ℃; for 8h;

DOI:10.1002/ejoc.201900644

Reference yield: 66.0%

ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate (106263-53-0) → ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate (1157864-92-0)

Guidance literature:

With Selectfluor; In acetonitrile; at 82 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.6b01641

Reference yield: 31.0%

ethyl 2-fluoroacetate (459-72-3) + 4-trifluoromethyl-phenyl acetyl chloride (329-15-7) → ethyl 2-fluoro-3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate (1157864-92-0)

Guidance literature:

ethyl 2-fluoroacetate; With lithium hexamethyldisilazane; Diphenylphosphinic chloride; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

4-trifluoromethyl-phenyl acetyl chloride; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00752

upstream raw materials:

ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

1-(4-trifluoromethylphenyl)ethanone

4-Trifluoromethylbenzaldehyde

ethyl 2-fluoroacetate

Downstream raw materials:

C₁₉H₁₇F₄NO₃