2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine

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Chemical Name:2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine
CAS No.:476468-46-9
Molecular Formula:C₁₈H₁₉N₅O₃
Molecular Weight:353.381
Hs Code.:

Synonyms:2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine

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Chemical Property of 2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine

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Technology Process of 2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine

There total 5 articles about 2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 96761-00-1
1,4-anhydro-2-deoxy-D-erythro-pent-1-enitol

: 476468-45-8
8-iodo-2-methyl-4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-4-one

: 476468-46-9
2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine

Guidance literature:: With tributyl-amine; triphenyl-arsane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; at 60 ℃; for 18h;
DOI:10.1021/jo026268l

Reference yield:

: 55457-17-5
2-methylpyrazolo<1,5-a>-s-triazin-4-one

: 476468-46-9
2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / N,N-dimethylaniline; POCl₃ / 2 h / Heating

2: 1.46 g / CH₂Cl₂ / 0 - 20 °C

3: 87 percent / N-iodosuccinimide / CHCl₃ / 0.5 h / Heating

4: 75 percent / bis(dibenzylideneacetone)palladium⁽⁰⁾; Ph₃As; (n-Bu)3N / acetonitrile / 18 h / 60 °C

With N-iodo-succinimide; tributyl-amine; triphenyl-arsane; N,N-dimethyl-aniline; bis(dibenzylideneacetone)-palladium⁽⁰⁾; trichlorophosphate; In dichloromethane; chloroform; acetonitrile;
DOI:10.1021/jo026268l

Reference yield:

: 121-69-7,77733-26-7
N,N-dimethyl-aniline

: 476468-46-9
2-methyl-4-(N-methyl-N-phenylamino)-8-(β-D-glycero-pentofuran-3'-ulose-1'-yl)pyrazolo[1,5-a]-1,3,5-triazine

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / POCl₃ / 4 h / 125 °C

2: 87 percent / N-iodosuccinimide / CHCl₃ / 0.5 h / Heating

3: 75 percent / bis(dibenzylideneacetone)palladium⁽⁰⁾; Ph₃As; (n-Bu)3N / acetonitrile / 18 h / 60 °C

With N-iodo-succinimide; tributyl-amine; triphenyl-arsane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; trichlorophosphate; In chloroform; acetonitrile;
DOI:10.1021/jo026268l