Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester

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Chemical Name:Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester
CAS No.:777096-47-6
Molecular Formula:C₃₄H₅₈O₇Si
Molecular Weight:606.916
Hs Code.:

Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester

Synonyms:Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester

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Chemical Property of Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester

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Technology Process of Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester

There total 13 articles about Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126889-55-2
diethyl(isopropyl)silyl trifluoromethanesulfonate

: 777096-47-6
Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2,6-lutidine

2.1: LiBH₄ / methanol; diethyl ether

3.1: DMAP; Et₃N

4.1: OsO₄; NMO

5.1: aq. NaIO₄

6.1: 97 percent / toluene / 17 h / -78 °C

7.1: K₂CO₃ / methanol

8.1: PPTs / acetone

9.1: 9-BBN / tetrahydrofuran; diethyl ether

9.2: aq. H₂O₂; NaOH / tetrahydrofuran; diethyl ether

10.1: Et₃N

With 2,6-dimethylpyridine; dmap; sodium periodate; osmium(VIII) oxide; lithium borohydride; 9-borabicyclo[3.3.1]nonane dimer; N-methyl-2-indolinone; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; acetone; toluene; 6.1: Roush crotylation;
DOI:10.1021/ja0289649

Reference yield:

: 220213-54-7
(E)-(R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-pent-2-en-1-ol

: 777096-47-6
Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: DMSO; (COCl)2; NEt₃ / -78 - 20 °C

2.1: Bu₂BOTf; Et₃N

3.1: 2,6-lutidine

4.1: LiBH₄ / methanol; diethyl ether

5.1: DMAP; Et₃N

6.1: OsO₄; NMO

7.1: aq. NaIO₄

8.1: 97 percent / toluene / 17 h / -78 °C

9.1: K₂CO₃ / methanol

10.1: PPTs / acetone

11.1: 9-BBN / tetrahydrofuran; diethyl ether

11.2: aq. H₂O₂; NaOH / tetrahydrofuran; diethyl ether

12.1: Et₃N

With 2,6-dimethylpyridine; dmap; sodium periodate; osmium(VIII) oxide; lithium borohydride; 9-borabicyclo[3.3.1]nonane dimer; N-methyl-2-indolinone; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; acetone; toluene; 1.1: Swern oxidation / 8.1: Roush crotylation;
DOI:10.1021/ja0289649

Reference yield:

: 648883-76-5
(E)-(R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-pent-2-enal

: 777096-47-6
Acetic acid (R)-3-{(4R,5S)-5-[(E)-(1S,4R)-1-(diethyl-isopropyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: Bu₂BOTf; Et₃N

2.1: 2,6-lutidine

3.1: LiBH₄ / methanol; diethyl ether

4.1: DMAP; Et₃N

5.1: OsO₄; NMO

6.1: aq. NaIO₄

7.1: 97 percent / toluene / 17 h / -78 °C

8.1: K₂CO₃ / methanol

9.1: PPTs / acetone

10.1: 9-BBN / tetrahydrofuran; diethyl ether

10.2: aq. H₂O₂; NaOH / tetrahydrofuran; diethyl ether

11.1: Et₃N

With 2,6-dimethylpyridine; dmap; sodium periodate; osmium(VIII) oxide; lithium borohydride; 9-borabicyclo[3.3.1]nonane dimer; N-methyl-2-indolinone; di-n-butylboryl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; acetone; toluene; 7.1: Roush crotylation;
DOI:10.1021/ja0289649