1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea

Base Information

Chemical Name:1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea
CAS No.:1288341-88-7
Molecular Formula:C₁₉H₁₆F₄N₆O
Molecular Weight:420.369
Hs Code.:

Synonyms:1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea

Suppliers and Price of 1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea

There total 3 articles about 1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1288339-40-1
4-[3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluoroaniline

: 541-41-3
chloroformic acid ethyl ester

: 157335-92-7
4‐methylpyrimidine‐5‐carboxylic acid

: 1288341-88-7
1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea

Guidance literature:: chloroformic acid ethyl ester; 4‐methylpyrimidine‐5‐carboxylic acid; In water; acetone; at -5 ℃; for 0.5h;

With sodium azide; In water; acetone; at -5 ℃; for 0.5h;

4-[3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluoroaniline; In 1,4-dioxane; for 0.5h; Reflux;

Reference yield:

: 1318763-41-5
5-cyclopropyl-1-(2-fluoro-4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole

: 1288341-88-7
1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / Reflux

2.1: water; acetone / 0.5 h / -5 °C

2.2: 0.5 h / -5 °C

2.3: 0.5 h / Reflux

With iron; ammonium chloride; In ethanol; water; acetone;

Reference yield:

: 110960-73-1
ethyl 4-methylpyrimidine-5-carboxylate

: 1288341-88-7
1-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorophenyl}-3-(4-methylpyrimidin-5-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / Reflux

1.2: 25 - 28 °C

2.1: water; acetone / 0.5 h / -5 °C

2.2: 0.5 h / -5 °C

2.3: 0.5 h / Reflux

With water; sodium hydroxide; In water; acetone;