(3R,4S,5S)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone

Base Information

• Chemical Name: (3R,4S,5S)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone
• CAS No.: 1391866-47-9
• Molecular Formula: C₁₇H₂₄INO₂
• Molecular Weight: 401.288
• Mol file: 1391866-47-9.mol

Synonyms:(3R,4S,5S)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone

Chemical Property of (3R,4S,5S)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (3R,4S,5S)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone

There total 1 articles about (3R,4S,5S)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-methoxy-2-methyl-N-[(1R)-1-phenyl-2-propen-1-yl]-2-propenamide + 2-iodo-propane (75-30-9) → (3S,4R,5R)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone + (3R,4R,5R)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone + (3R,4S,5S)-4-(iodomethyl)-1-methoxy-3-methyl-3-(2-methylpropyl)-5-phenyl-2-pyrrolidinone (1391866-47-9)

Guidance literature:

N-methoxy-2-methyl-N-[(1R)-1-phenyl-2-propen-1-yl]-2-propenamide; With zinc trifluoromethanesulfonate; {3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole}; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

2-iodo-propane; With triethyl borane; In hexane; dichloromethane; at -40 ℃; optical yield given as %ee; Inert atmosphere;

DOI:10.1039/c2ob25073j

upstream raw materials:

2-iodo-propane