methyl 1-((S)-1-phenylethyl)-1H-indole-3-carboxylate

Base Information

• Chemical Name: methyl 1-((S)-1-phenylethyl)-1H-indole-3-carboxylate
• CAS No.: 1030593-94-2
• Molecular Formula: C₁₈H₁₇NO₂
• Molecular Weight: 279.338
• Mol file: 1030593-94-2.mol

Synonyms:methyl 1-((1S)-1-phenylethyl)-1H-indole-3-carboxylate

Chemical Property of methyl 1-((S)-1-phenylethyl)-1H-indole-3-carboxylate

Chemical Property:

Purity/Quality:

methyl1-((S)-1-phenylethyl)-1H-indole-3-carboxylate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-((S)-1-phenylethyl)-1H-indole-3-carboxylate

There total 2 articles about methyl 1-((S)-1-phenylethyl)-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl α-formyl(o-bromophenyl)acetate (122394-37-0) + (S)-1-phenyl-ethylamine (2627-86-3) → methyl 1-((1S)-1-phenylethyl)-1H-indole-3-carboxylate (1030593-94-2,1260589-49-8)

Guidance literature:

methyl α-formyl(o-bromophenyl)acetate; (S)-1-phenyl-ethylamine; In methanol; at 20 ℃; for 6h;

With potassium phosphate; copper(l) iodide; In N,N-dimethyl-formamide; at 75 ℃; for 9h; Further stages.;

DOI:10.1021/jo800630v

Reference yield:

C18H18BrNO2 → methyl 1-((1S)-1-phenylethyl)-1H-indole-3-carboxylate (1030593-94-2,1260589-49-8)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 135 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02784

upstream raw materials:

methyl α-formyl(o-bromophenyl)acetate

(S)-1-phenyl-ethylamine

Refernces

• 1、 Melkonyan, Ferdinand S.,Karchava, Alexander V.,Yurovskaya, Marina A.. "Synthesis of N-substituted indole-3-carboxylic acid derivatives via Cu(I)-catalyzed intramolecular amination of aryl bromides". . p. 4275 - 4278. Retrieved 2008/09/20.