H-PRO-PRO-OH HCL

Base Information

• Chemical Name: H-PRO-PRO-OH HCL
• CAS No.: 76932-06-4
• Molecular Formula: C₁₀H₁₆N₂O₃*ClH
• Molecular Weight: 248.71
• Hs Code.: 2933990090
• Mol file: 76932-06-4.mol

Synonyms:L-Proline,1-L-prolyl-, monohydrochloride; L-Proline, L-prolyl-, monohydrochloride (9CI)

Chemical Property of H-PRO-PRO-OH HCL

Chemical Property:

• Melting Point: 172 °C
• PSA: 69.64000
• LogP: 0.88270
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

1-L-Prolyl-L-prolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-L-Prolyl-L-proline Hydrochloride, is a building block used in the synthesis of various compounds such as in synthetic preparation of bis-cystinyl cyclic peptides.

Technology Process of H-PRO-PRO-OH HCL

There total 5 articles about H-PRO-PRO-OH HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-prolyl>proline (121252-83-3) → N-prolylproline hydrochloride (76932-06-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃;

DOI:10.1021/jo00277a054

Reference yield:

D-Prolin (344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → N-prolylproline hydrochloride (76932-06-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / SOCl₂

2: Et₃N / 6 h / 0 °C

3: 76.3 percent / LiOH*H₂O, H₂O / tetrahydrofuran; methanol / 5 h / 60 °C / various bases, other time and temperature

4: 71 percent / HCl(g) / diethyl ether / 0 °C

With hydrogenchloride; lithium hydroxide; thionyl chloride; water; triethylamine; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1021/jo00277a054

Reference yield:

N-(dibutyloxyphosphinyl)proline (121252-81-1) → N-prolylproline hydrochloride (76932-06-4)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N, CCl₄ / CH₂Cl₂ / 10 h / 0 °C

2: Et₃N / 6 h / 0 °C

3: 76.3 percent / LiOH*H₂O, H₂O / tetrahydrofuran; methanol / 5 h / 60 °C / various bases, other time and temperature

4: 71 percent / HCl(g) / diethyl ether / 0 °C

With hydrogenchloride; tetrachloromethane; lithium hydroxide; water; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

DOI:10.1021/jo00277a054

upstream raw materials:

N-prolyl>proline

N-(dibutyloxyphosphinyl)proline

N-proline methyl ester

D-Prolin

Refernces