N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide

Base Information

Chemical Name:N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide
CAS No.:1300729-33-2
Molecular Formula:C₂₃H₂₅N₃O₃
Molecular Weight:391.47
Hs Code.:

Synonyms:N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide

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Chemical Property of N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide

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Technology Process of N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide

There total 5 articles about N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 2434-00-6
(tetrahydro-furan-2-yl)-acetic acid

: 1300730-07-7
4-(2-(2-(1-trityl-1H-imidazol-4-yl)phenoxy)ethyl)aniline

: 1300729-33-2
N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide

Guidance literature:: (tetrahydro-furan-2-yl)-acetic acid; 4-(2-(2-(1-trityl-1H-imidazol-4-yl)phenoxy)ethyl)aniline; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With acetic acid; In methanol; at 80 ℃; for 2h;

With sodium hydroxide; In methanol; water;

Reference yield:

: 104-10-9
2-(4'-aminophenyl)ethyl alcohol

: 1300729-33-2
N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 1 h / 100 °C

2.1: pyridine / dichloromethane / 16 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3.2: Inert atmosphere

4.1: hydrazine hydrate / ethanol / 2 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.2: 2 h / 80 °C

With pyridine; sodium hydride; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: C₄₄H₃₃N₃O₃

: 1300729-33-2
N-(4-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)phenyl)-2-(tetrahydrofuran-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 2 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

2.2: 2 h / 80 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide;