2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

Base Information

Chemical Name:2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine
CAS No.:1445830-39-6
Molecular Formula:C₂₄H₂₄F₂N₆O₃
Molecular Weight:482.49
Hs Code.:

Synonyms:2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

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Chemical Property of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

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Technology Process of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

There total 5 articles about 2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1445831-24-2
2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

: 19524-06-2
4-bromopyridine hydrochloride

: 1445830-39-6
2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Inert atmosphere;

Reference yield:

: 759-65-9
diethyl oxalpropionate

: 1445830-39-6
2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2: potassium carbonate / acetone / 48 h / 20 °C

3: trimethylaluminum; ammonium chloride / n-heptane; toluene / 24 h / 80 °C / Inert atmosphere

4: piperidine / i-Amyl alcohol / 24 h / 100 °C / Inert atmosphere

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate / N,N-dimethyl-formamide / 24 h / 110 °C / Inert atmosphere

With piperidine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trimethylaluminum; potassium carbonate; ammonium chloride; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; In 1,4-dioxane; i-Amyl alcohol; n-heptane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1445831-06-0
ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazole-3-carboxylate

: 1445830-39-6
2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylaluminum; ammonium chloride / n-heptane; toluene / 24 h / 80 °C / Inert atmosphere

2: piperidine / i-Amyl alcohol / 24 h / 100 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate / N,N-dimethyl-formamide / 24 h / 110 °C / Inert atmosphere

With piperidine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trimethylaluminum; ammonium chloride; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; In i-Amyl alcohol; n-heptane; N,N-dimethyl-formamide; toluene;