2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

Base Information

Chemical Name:2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine
CAS No.:1445831-24-2
Molecular Formula:C₁₉H₂₁F₂N₅O₃
Molecular Weight:405.404
Hs Code.:

Synonyms:2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

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Chemical Property of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

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Technology Process of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

There total 4 articles about 2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 426813-74-3
3,3-bis(dimethylamino)-2-methoxypropanenitrile

: 1445831-09-3
1-(4-ethoxy-2,6-difiuorobenzyl)-5-methoxy-4-methyl-1H-pyrazole-3-carboximidamide hydrochloride

: 1445831-24-2
2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

Guidance literature:: With piperidine; In i-Amyl alcohol; at 100 ℃; for 24h; Inert atmosphere;

Reference yield:

: 1445830-97-6
ethyl 1-(4-ethoxy-2,6-difluorobenzyl)-5-hydroxy-4-methyl-1H-pyrazole-3-carboxylate

: 1445831-24-2
2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 48 h / 20 °C

2: trimethylaluminum; ammonium chloride / n-heptane; toluene / 24 h / 80 °C / Inert atmosphere

3: piperidine / i-Amyl alcohol / 24 h / 100 °C / Inert atmosphere

With piperidine; trimethylaluminum; potassium carbonate; ammonium chloride; In i-Amyl alcohol; n-heptane; acetone; toluene;

Reference yield:

: 759-65-9
diethyl oxalpropionate

: 1445831-24-2
2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2: potassium carbonate / acetone / 48 h / 20 °C

3: trimethylaluminum; ammonium chloride / n-heptane; toluene / 24 h / 80 °C / Inert atmosphere

4: piperidine / i-Amyl alcohol / 24 h / 100 °C / Inert atmosphere

With piperidine; trimethylaluminum; potassium carbonate; ammonium chloride; acetic acid; In 1,4-dioxane; i-Amyl alcohol; n-heptane; acetone; toluene;