(E)-diethyl 2-(1-benzylidene-4-bromo-1,2-dihydronaphthalen-2-yl)malonate

Base Information

Chemical Name:(E)-diethyl 2-(1-benzylidene-4-bromo-1,2-dihydronaphthalen-2-yl)malonate
CAS No.:1333506-63-0
Molecular Formula:C₂₄H₂₃BrO₄
Molecular Weight:455.348
Hs Code.:

Synonyms:(E)-diethyl 2-(1-benzylidene-4-bromo-1,2-dihydronaphthalen-2-yl)malonate

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Chemical Property of (E)-diethyl 2-(1-benzylidene-4-bromo-1,2-dihydronaphthalen-2-yl)malonate

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Technology Process of (E)-diethyl 2-(1-benzylidene-4-bromo-1,2-dihydronaphthalen-2-yl)malonate

There total 2 articles about (E)-diethyl 2-(1-benzylidene-4-bromo-1,2-dihydronaphthalen-2-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1333506-56-1
1-bromo-4-(chloro(phenyl)methyl)naphthalene

: 105-53-3
diethyl malonate

: 1333506-63-0
(E)-diethyl 2-(1-benzylidene-4-bromo-1,2-dihydronaphthalen-2-yl)malonate

Guidance literature:: 1-bromo-4-(chloro(phenyl)methyl)naphthalene; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃;

diethyl malonate; With sodium hydride; In tetrahydrofuran; mineral oil; for 12h; Inert atmosphere;
DOI:10.1021/ol2023278

Reference yield:

: 1333506-84-5
C₁₇H₁₃BrO

: 1333506-63-0
(E)-diethyl 2-(1-benzylidene-4-bromo-1,2-dihydronaphthalen-2-yl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 20 °C

2.2: 12 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol2023278