3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

Base Information

Chemical Name:3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
CAS No.:1620011-34-8
Molecular Formula:C₂₄H₂₃F₃N₆O₂
Molecular Weight:484.481
Hs Code.:

Synonyms:3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

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Chemical Property of 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

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Technology Process of 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

There total 11 articles about 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₁F₃N₆O₄

: 1620011-34-8
3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; at 20 - 30 ℃; for 0.5h;

Reference yield:

: 113975-22-7
2-fluoro-3-iodopyridine

: 1620011-34-8
3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1.5 h / -78 °C

1.2: 2.67 h / -78 - 30 °C

1.3: 3 h / 0 - 30 °C

2.1: potassium phosphate / 1,4-dioxane / 36 h / Reflux

3.1: sulfuric acid; nitric acid / 16 h / -10 - 30 °C

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 100 °C / Sealed tube; Microwave irradiation

5.1: hydrogen; palladium 10% on activated carbon / methanol / 14 h / 760.05 Torr / Inert atmosphere

6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 - 30 °C

7.1: trifluoroacetic acid / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 - 30 °C

With potassium phosphate; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide;

Reference yield:

: 1620011-25-7
2-(2-fluoro-4-iodopyridin-3-yl)ethane-1-ol

: 1620011-34-8
3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate / 1,4-dioxane / 36 h / Reflux

2: sulfuric acid; nitric acid / 16 h / -10 - 30 °C

3: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 100 °C / Sealed tube; Microwave irradiation

4: hydrogen; palladium 10% on activated carbon / methanol / 14 h / 760.05 Torr / Inert atmosphere

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 - 30 °C

6: trifluoroacetic acid / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 - 30 °C

With potassium phosphate; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;