113975-22-7

Basic information

• Product Name: 2-Fluoro-3-iodopyridine
• Synonyms: PYRIDINE, 2-FLUORO-3-IODO-;2-FLUORO-3-IODOPYRIDINE;2-Fluoro-3-iodopyridine ,98%;2-Fluoro-3-Iodopyridine 98%;2-Fluoro-3-iodopyridine, 97+%
• CAS NO: 113975-22-7
• Molecular Formula: C₅H₃FIN
• Molecular Weight: 222.99
• Product Categories: Pyridine;Pyridine series;Halides;Pyridines;Heterocycle;Propidium heterocyclic series;Building Blocks;C5;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;New Products for Chemical Synthesis;Other Fluorinated Heterocycles;Fluorine series;alkyl Iodine| alkyl Fluorine
• Mol File: 113975-22-7.mol
• Article Data: 38

Chemical Properties

• Melting Point: 45 °C
• Boiling Point: 99°C/17mmHg(lit.)
• Flash Point: >110°C
• Appearance: Salmon-coloured solid
• Density: 2.046 g/cm³
• Vapor Pressure: 0.1mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Refrigerated.
• PKA: -2.45±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-Fluoro-3-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-iodopyridine(113975-22-7)
• EPA Substance Registry System: 2-Fluoro-3-iodopyridine(113975-22-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38-41-37/38
• Safety Statements: 22-26-36/37/39-39-37
• WGK Germany: 3
• Hazardous Substances Data: 113975-22-7(Hazardous Substances Data)

Usage

Chemical Properties

Salmon-coloured solid

InChI:InChI=1/C5H3FIN/c6-5-4(7)2-1-3-8-5/h1-3H

Upstream product

• 372-48-5 2-fluoropyridine 
• 79574-82-6 3-Lithio-2-fluoropyridine 
• 36178-05-9 3-bromo-2-fluoropyridine 
• 78607-36-0 2-chloro-3-iodopyridine 

Downstream Products

• 112197-15-6 3-iodo-2-methoxypyridine 
• 146141-05-1 2,2-dimethyl-N-(2-(2-fluoro-3-pyridyl)phenyl)propanamide 
• 104830-06-0 3-iodo-2-aminopyridine 
• 22282-70-8 2-fluoro-4-iodopyridine 
• 153034-82-3 [(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde 
• 214074-22-3 N-Cyclopropyl-3-iodo-pyridin-2-amine 
• 428861-79-4 [2-(2-fluoro-pyridin-3-yl)-3-methoxy-phenyl]-carbamic acid tert-butyl ester 
• 655245-95-7 3-benzyl-2-fluoro-4-iodo-pyridine 
• 744257-63-4 1-(2-fluoro-4-iodo-pyridin-3-yl)-ethanol 
• 340268-75-9 3-allyl-2-fluoro-4-iodo-pyridine 
• 436844-92-7 4-(2-fluoro-3-pyridinyl)-3-butyn-1-ol 
• 158669-26-2 4-iodo-2-methoxynicotinaldehyde 
• 1177267-50-3 (trans)-8-({[6-(2-fluorophenyl)-3-pyridazinyl]amino}methyl)-3-(2-fluoro-3-pyridinyl)-1-oxa-3-azaspiro[4.5]decan-2-one 
• 1177267-48-9 (trans)-8-({[6-(3-fluorophenyl)-3-pyridazinyl]amino}methyl)-3-(2-fluoro-3-pyridinyl)-1-oxa-3-azaspiro[4.5]decan-2-one 

Relevant articles and documents

Deprotonation of fluoro aromatics using lithium magnesates

Activated fluoro aromatics are deprotonated using lithium magnesates. 3-Fluoropyridine was deprotonated on treatment with 1/3 equiv of Bu 3MgLi in THF at -10°C. The lithium arylmagnesate formed was either trapped with electrophiles or involved

Facile preparation of 3-substituted-2,6-difluoropyridines: Application to the synthesis of 2,3,6-trisubstituted pyridines

We report a facile method for the difluorination of 3-substituted-2,6-dichloropyridines using cesium fluoride as a fluorination reagent in dimethyl sulfoxide. It is proposed that this method for preparing 3-substituted-2,6-difluoropyridines is simpler and easier than those reported in previous literature. To examine the utility of 3-substituted-2,6-difluoropyridines in synthetic chemistry, we also demonstrate a subsequent conversion to 2,3,6-trisubstituted pyridines by a tandem nucleophilic aromatic substitution.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

HETEROCYCLIC COMPOUND

The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.