(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

Base Information

Chemical Name:(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone
CAS No.:101758-68-3
Molecular Formula:C₂₄H₂₀O₃
Molecular Weight:356.421
Hs Code.:

Synonyms:(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

Chemical Property:

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Technology Process of (R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

There total 1 articles about (R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 112837-17-9
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

: 76-83-5
trityl chloride

: 101758-68-3
(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

Guidance literature:: In pyridine; ethanol;

Reference yield: 52.0%

: 101758-68-3
(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

: 113626-56-5
(2S,3S,4S)-2,3-dihydroxy-4-trityloxymethyl-4-butanolide

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; Ambient temperature;
DOI:10.1248/cpb.38.2712

Reference yield:

: 101758-68-3
(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

: 72741-87-8
swainsonine

Guidance literature:: Multi-step reaction with 11 steps

1: 52 percent / OsO₄, N-methylmorpholine N-oxide / H₂O; acetone

2: p-TsOH / acetone

3: 1.) LiAlH₄; 2.) pyridine; 3.) NaN₃ / 1.) THF; 3.) DMF, 130 deg C

4: 65 percent / H₂ / Pd black / ethanol

5: K₂CO₃ / ethanol

6: cc. HCl / methanol

7: 1.) copper(I) iodide / 1.) Swern oxidation; 2.) THF, -78 deg C, dimethylsulfide

8: NaH / tetrahydrofuran; dimethylformamide

9: 1.) BH₃; 2.) 30 percent H₂O₂, 12 percent NaOH / 1.) THF

10: mesyl chloride, triethylamine / CH₂Cl₂

With pyridine; hydrogenchloride; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; sodium azide; borane; hydrogen; dihydrogen peroxide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; osmium(VIII) oxide; palladium; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.35.2140