(R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate
CAS No.:1133749-73-1
Molecular Formula:C₁₇H₂₈F₂N₂O₃
Molecular Weight:346.418
Hs Code.:

Synonyms:(R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate

There total 1 articles about (R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 122665-97-8
4,4-difluorocyclohexanecarboxylic acid

: 147081-29-6
(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1133749-73-1
(R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 15h;

Reference yield:

: 1133749-73-1
(R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate

: 1133749-76-4
(S)-(4,4-difluorocyclohexyl)(2-methylpiperazin-1-yl)methanone

Guidance literature:: (R)-tert-butyl 4-(4,4-difluorocyclohexanecarbonyl)-3-methylpiperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With potassium carbonate; In dichloromethane; water;