Technology Process of N-benzyl-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide
There total 7 articles about N-benzyl-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
Inert atmosphere;
benzyl bromide;
With
potassium iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 5h;
Inert atmosphere;
DOI:10.1016/j.ejmech.2013.07.050
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere
3.1: triphenylphosphine / water; tetrahydrofuran / 20 °C
4.1: hydrogenchloride
5.1: triethylamine / dichloromethane / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
6.2: 5 h / 20 °C / Inert atmosphere
With
hydrogenchloride; diphenyl phosphoryl azide; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
3.1: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; 1,2-dimethoxyethane / 12 h / 85 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere
4.1: triphenylphosphine / water; tetrahydrofuran / 20 °C
5.1: hydrogenchloride
6.1: triethylamine / dichloromethane / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
7.2: 5 h / 20 °C / Inert atmosphere
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); diphenyl phosphoryl azide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
1.1: |Suzuki Coupling / 4.1: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050
