Technology Process of 9-<4-hydroxy-3-(hydroxymethyl)but-1-yl>xanthine
There total 6 articles about 9-<4-hydroxy-3-(hydroxymethyl)but-1-yl>xanthine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 41 percent / p-TsOH*H2O / tetrahydrofuran / 0.5 h / Ambient temperature
2: 87 percent / CBr4, PPh3 / dimethylformamide / 0.5 h / 0 °C
3: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature
4: 72 percent / 2.0 M HCl / 1.25 h / Heating
5: 60 percent / aq. HCl, sodium nitrite / 0.5 h
With
hydrogenchloride; carbon tetrabromide; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; sodium nitrite;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00392a020
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / sodium borohydride, MeOH / 2-methyl-propan-2-ol / 0.5 h / Heating
2: 41 percent / p-TsOH*H2O / tetrahydrofuran / 0.5 h / Ambient temperature
3: 87 percent / CBr4, PPh3 / dimethylformamide / 0.5 h / 0 °C
4: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature
5: 72 percent / 2.0 M HCl / 1.25 h / Heating
6: 60 percent / aq. HCl, sodium nitrite / 0.5 h
With
hydrogenchloride; methanol; sodium tetrahydroborate; carbon tetrabromide; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; sodium nitrite;
In
tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00392a020
